What's Really Important in a Woman's Lipid Profile?

Prospective data from the Women's Health Initiative suggest that HDL level is a significant inverse predictor of coronary events, regardless of LDL level.

An inverse association exists between HDL level and cardiovascular disease. In men, this association has been found to be independent of LDL level. To find out if the association is consistent across the spectrum of LDL or apolipoprotein (apoA-I and apoB100) levels in women, researchers conducted an industry-sponsored analysis of data involving 26,861 participants in the Women's Health Study. All were aged ≥45 and healthy at baseline.

During approximately 11 years of follow-up, 929 cardiovascular events occurred, including 602 coronary events and 319 strokes. In multivariate analysis, HDL and apoA-I levels were inversely associated with risk for coronary events (but not for stroke). This association was consistent in subgroups stratified by …

Reviewing Author

Joel M. Gore, MD

Disclosures

Grant/Research SupportNIH–National Heart, Lung, and Blood Institute

Joel M. Gore, MD

Disclosures

Grant/Research SupportNIH–National Heart, Lung, and Blood Institute

What's Really Important in a Woman's Lipid Profile?

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Reviewing Author