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Debate continues about the cardiovascular benefits or harms of hormone replacement therapy (HT). Despite guideline recommendations to discontinue HT in patients with coronary artery disease, as many as 80% of women taking HT at the time of hospitalization for myocardial infarction (MI) continue HT after discharge. To assess whether continuation or discontinuation of HT after MI affects risk for adverse cardiovascular events, investigators studied Danish nationwide registry data on women hospitalized with MI.
During 1997–2008, 3322 female MI survivors aged 40 or older had HT prescriptions at the index hospitalization. Most used combined systemic estrogen and progestogen (33.1%), vaginal estrogen (29.4%), or systemic estrogen alone (28.7%); on…