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Stress is frequently blamed for cardiac disease, and depression has been associated with sudden cardiac death (JW Cardiol Jun 10 2005). However, whether negative affect is linked to atrial fibrillation (AF) is not clear. The Women's Health Study included 39,876 women free of cardiovascular disease who were randomized to receive vitamin E, low-dose aspirin, both, or neither for primary prevention of cancer and cardiovascular disease. Of these, 30,746 with adequate follow-up and complete Mental Health Inventory-5 data were included in the present analysis.
During a median follow-up of 125 months, 2089 (6.8%) women reported substantial psychological distress, and 771 (2.5%) had new-onset AF. Neither global psychological distress nor depression …