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Evaluation of chest pain often involves testing for either anatomic coronary disease or functional ischemia. In this multicenter study, 252 stable patients with suspected coronary artery disease underwent invasive coronary angiography with fractional flow reserve (CA-FFR; the reference standard for assessing the hemodynamic significance of coronary lesions) and noninvasive computed tomographic angiography with a new computerized analysis of flow reserve (CTA-FFR; calculation takes ≈6 hours). The primary endpoint was a per-patient estimated diagnostic accuracy significantly higher than 70% for CTA-FFR as compared with CA-FFR. The study was funded by a company interested in developing CTA-FFR, which also served as the core lab for CTA-FFR.
One…