In the CARRESS trial, the procedure was less effective than a diuretic-based approach for preserving renal function.
Managing cardiorenal syndrome in patients with acute decompensated heart failure (ADHF) is a considerable challenge. Diuretics — the mainstay of treatment for volume overload in ADHF — can worsen renal function in such patients. Ultrafiltration, a mechanical approach to volume removal, has been proposed as an alternative approach.
In the National Heart, Lung, and Blood Institute–sponsored CARRESS trial, investigators enrolled 188 patients (median age, 68; 75% men; median left ventricular ejection fraction [LVEF], 33%) with a serum creatinine increase of at least 0.3 mg/dL during 12 weeks before to 10 days after admission for ADHF. LVEF was not an enrollment factor; patients with severe renal dysfunction were excluded. Patients were randomize…
Reviewing Author
DisclosuresConsultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research
Grant/Research SupportNational Heart, Lung, and Blood Institute
Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)
Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)
DisclosuresConsultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research
Grant/Research SupportNational Heart, Lung, and Blood Institute
Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)
Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)