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Cardiac resynchronization therapy (CRT), or biventricular pacing, is beneficial in patients with wide QRS complexes and left ventricular ejection fractions (LVEFs) less than 35%. However, the benefits of CRT have rarely been tested in patients with LVEFs greater than 35%. In the BLOCK HF trial, investigators enrolled individuals with LVEFs ≤50% who had an indication for a pacemaker because of atrioventricular (AV) block or markedly prolonged PR interval on AV-node conduction testing.
In all, 691 patients in the U.S. and Canada received a biventricular pacemaker or, if indicated, a biventricular implantable cardioverter-defibrillator. Patients were randomized to right ventricular (RV) or biventricular pacing. During a mean follow-up of 37 mon…