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Mesotherapy is a technique that delivers vitamins, herbal extracts, and other ingredients to the mesodermal layer of the skin. Mesotherapy using multivitamin injections as an anti-aging skin treatment has been touted and used by many medical and nonmedical practitioners, despite the existence of only anecdotal reports of its effectiveness. In a prospective study, 10 patients underwent four sessions of facial mesotherapy using multivitamins at monthly intervals. Under topical anesthesia, they received intradermal injections spaced 1 centimeter apart across the whole face. This translated into 200 to 250 injection sites. Biopsy samples were obtained before treatment and 2 months after the last treatment. Photographs were taken throughout the …