Mycosis Fungoides and Sézary Syndrome Patients at Risk for a Second Malignancy

Several studies have suggested that patients with mycosis fungoides (MF) and Sézary syndrome (SS) have an increased incidence of second malignancies compared with the general population. Huang and colleagues examined this issue in detail by analyzing two large cancer registries — the Surveillance, Epidemiology, and End Results Program (SEER-9) and the Stanford University lymphoma cohort — for second primary cancers in MF and SS patients.

In both cohorts, there was a slight increase in second cancers compared with the general population. The incidence of Hodgkin disease in MF and SS patients was 17 to 27 times greater than expected for the general population. Researchers also found statistically significant increases in non-Hodgkin lymphoma, …