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The field of available filler materials is growing crowded, with new ones approved every few months. Investigators of this prospective, multicenter, placebo-controlled study examined the viability of injecting autologous fibroblasts, instead of an inert material, with the goal of producing new collagen.
A post-auricular punch biopsy sample was taken from each of 151 patients, and the tissue was processed to generate an autologous fibroblast culture. Patients randomly received, at a 3:1 ratio, three injections, 1 or 2 weeks apart, of cultured fibroblasts (concentration, 10 million cells/mL) or the carrier material (placebo) into acne scars or wrinkles in the superficial dermis. At the 6-month follow-up, placebo recipients were offered the opp…