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High-frequency (100-kHz to 1000-kHz) alternating current (AC) affects dividing malignant cells by directing dipolar molecules toward the mitotic cleavage, but high membrane impedance allows only a fraction of the electric field to enter the cell. Conventional wisdom suggests that AC of this frequency has no significant biologic effects. In previous research, investigators showed that low-intensity, intermediate-frequency electric fields inhibited intradermal melanoma in mice by an antimicrotubule mechanism. Now, in an industry-sponsored study, the same group treated 10 patients with recurrent glioblastoma multiforme with a device that uses tumor-treating electric fields (TTfs). The patients wore, continuo…