Briefly Noted

In which we learn about drug reactions, mycophenolate mofetil, methotrexate, anti–TNF-α agents, corticosteroids, calciphylaxis, juvenile dermatomyositis, and porphyria

The literature is packed with articles of interest to practicing dermatologists — more than we can cover as regular Journal Watch Dermatology summaries. In this column, which will appear periodically, we will present brief reviews of articles of interest along with a bottom-line message. Many of the articles will be reviews or case reports, but some full-length articles might also be discussed.

— Jeffrey P. Callen, MD

Pharmacogenetics of Severe Drug Reactions

The search for genetic predictors of drug sensitivity is important, especially when severe reactions such as TEN or SJS may result. In a recent report, researchers examined the relation between HLA class I and class II gene polymorphisms and Stevens-Johnson syndrome in Japanese patients.1…