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Stem cells in the follicles may develop differently depending on location. Stem cells localized in the bulge are thought to be involved in the cyclical regeneration of hair follicles. Immunohistochemical markers can be used to identify stem cell types. To date, the best marker for bulge stem cells is CK15. Comparing the expression of CK15 and two antibody markers that target stem cells in other areas of the hair (CD34 and nestin), these authors examined the role of stem cells in the development of scarring and nonscarring alopecias.
The researchers examined 84 alopecia tissue samples (50 scarring and 34 nonscarring). The scarring group included patients with lupus erythematosus, lichen planopilaris, folliculitis decalvans, dissecting celluli…