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Obtaining adequate levels of vitamin D is essential for health: What constitutes an adequate level and how best to obtain it have been the subject of many recent research reports. There are only three sources of vitamin D — sunlight, food, and supplements. Dermatologists have taken the position that exposure to sunlight is not a good solution for the prevention of vitamin D deficiency, because of concerns about skin cancer and other adverse effects of ultraviolet radiation. But can dietary sources and supplementation provide sufficient vitamin D for health and disease prevention? In this issue, we review three new research articles in depth and provide links to other coverage that explores the complexity of this issue.