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One or two of every 100,000 women will develop vulvar squamous cell carcinoma (vSCC) each year. Changes in the Tp53 gene are the most common cancer-related genetic alterations in humans. Alterations in Tp53 may elucidate the relationship between differentiated vulvar intraepithelial neoplasm (dVIN) and vSCC.
The authors conducted a retrospective study of 11 consecutive cases of dVIN occurring during a 3-year period in one referral center; 6 cases were associated with vSCC. Six of the dVIN showed one or more Tp53 mutations. Missense or splice mutations were associated with positive immunohistochemical p53 staining; deletions were associated with negative stains. Exons 5 to 9 were the most frequently affected segment in mutated Tp53 cases. Fou…