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For a lesion with clear cell cytoplasm, particularly in the periocular area, the differential diagnosis includes processes arising from keratinocytes, melanocytes, sebocytes, and macrophages. Because sebaceous carcinoma is aggressive, its reliable identification is important. Adipophilin, a protein found on the surface of lipid droplets on many cells, is involved in lipid homeostasis of adipocytes and macrophages. Authors of a retrospective study recently explored the efficacy of adipophilin antibody testing in the diagnosis of sebaceous lesions.
The authors performed immunohistochemical staining in 117 cutaneous clear cell lesions (25 sebaceous carcinomas, 16 sebaceous adenomas, 13 metastatic renal cell carcinomas, 12 squamous cell carcinom…