Is Cutaneous Langerhans Cell Histiocytosis in Infants Self-Regressing?

Cutaneous Langerhans cell histiocytosis (LCH) is a spectrum of diseases encompassing eosinophilic granuloma, Hand-Schüller-Christian disease, Letterer-Siwe disease, and Hashimoto-Pritzker disease (aka congenital self-healing reticulohistiocytosis). The Hashimoto-Pritzker type classically presents at birth or in early infancy as cutaneous lesions that regress spontaneously in weeks to months; the prognosis is excellent. However, there is a nonregressing variant. Investigators seeking to better describe infantile LCH and define predictors of disease evolution performed a retrospective observational survey in a tertiary-care pediatric dermatology center.

Of 31 patients with cutaneous LCH presenting in the first 3 months of life, 21 had self-reg…