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The skin may be thought of as the window to the rest of body, because many internal diseases have prominent or diagnostic skin manifestations. The skin may also be thought of as a door because of its ability to deliver drugs and hormones via patches. Stratum corneum permeability can be increased by physical (ultrasonic or laser) or chemical modification of its properties. Authors of a recent report developed an alternative approach to delivering more drug, building sophisticated patches that can switch from a low-flow to a high-flow mode and are powered by a small watch battery.
Skin patches are often used to decrease the loss of drug via liver metabolism to maintain relatively constant levels of a drug. Variable-flow tr…