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Cellular angiofibromas (CAF) are benign mesenchymal tumors made up of bland spindle cells and prominent small-to-medium vessels with mural hyalinization. They occur in the groin and external genitalia of both sexes. Researchers studied the consequence of atypia or sarcomatous transformation in CAF in a single-center case review.
During 12 years, 13 cases of sarcomatous transformation were identified among 154 cases of typical CAF. Most patients were female; the median age was 46; and 85% of the tumors occurred in the subcutaneous tissue of the vulva, ranging in size from 1.2 to 7.5 cm. Four cases showed cellular atypia represented by scattered cells with hyperchromatic large nuclei in discontiguous foci within conventional CAF; the rest show…