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Lymphomatoid papulosis (LyP) is a recurrent, self-healing, waxing and waning, papular and nodular eruption that has traditionally had three recognized histologic subtypes — A, B, and C. A newly described variant has clinical features typical of LyP but also has histopathologic aspects that can resemble primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (which has a very poor prognosis).
These authors reviewed 26 biopsy samples from nine LyP CD8+ patients (6 male; median age, 29) who had presented with recurrent, self-healing papules and small, ulcerated, crusty nodules without lymphadenopathy, constitutional symptoms, or evidence of systemic disease. Histology revealed the presence of epidermotropic, atypical βF1+, CD…