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Ferguson-Smith syndrome, also known as multiple self-healing squamous epithelioma, is an autosomal dominant predisposition, often starting in adolescence, to develop spontaneously resolving squamous epitheliomas or keratoacanthomas (KAs) in sun-exposed areas or sites of trauma. These lesions typically form rapidly and regress spontaneously within weeks, resolving as scars. Relying on previous location of the genetic defect on a region of chromosome 9q22, these authors used high-throughput sequencing to identify 11 distinct mutations in the transforming growth factor beta receptor 1 gene (TGFβR1) in 18 predominantly Scottish affected kindreds. TGFβR1 is a transmembrane receptor that transduces signals from TGF-β, a protein that controls prol…