Tape stripping of the stratum corneum produced highly sensitive and specific melanoma identification.
An accurate genetic fingerprint for melanoma may finally be available through common “dust.” Tape stripping of the stratum corneum has been used in skin research for some time. Investigators conducted a trial of an epidermal genetic information retrieval (EGIR) system, which uses a custom adhesive film to noninvasively sample RNA from the stratum corneum, enabling such downstream applications as expression analysis.
These investigators, some of whom serve on the advisory board and some as employees of the manufacturer, used EGIR to sample skin overlying pigmented lesions: 29 melanomas (in situ and invasive) and 68 nevi (benign and atypical), and 15 normal skin specimens. RNA from the tape was subjected to transcriptome analysis, and computat…
Reviewing Author
DisclosuresConsultant / advisory board Lubax; WorldCare Clinical
EquityLubax
Grant / Research support NIH; Department of Defense; American Skin Association; Piramal
Editorial boardsBritish Journal of Dermatology; Journal of the American Academy of Dermatology; Journal of Investigative Dermatology
Leadership positions in professional societies American Academy of Dermatology (Chair, Skin Cancer and Melanoma Committee); American Board of Dermatology (Director)
DisclosuresConsultant / advisory board Lubax; WorldCare Clinical
EquityLubax
Grant / Research support NIH; Department of Defense; American Skin Association; Piramal
Editorial boardsBritish Journal of Dermatology; Journal of the American Academy of Dermatology; Journal of Investigative Dermatology
Leadership positions in professional societies American Academy of Dermatology (Chair, Skin Cancer and Melanoma Committee); American Board of Dermatology (Director)