Presence of IgA in Vessels Predicts Henoch-Schönlein Purpura

No other histologic features were significantly associated with HSP, but whether IgA deposition affects prognosis is still unknown.

Henoch-Schönlein purpura (HSP) is a type of vasculitis characterized by palpable purpura and associated with arthritis, glomerulonephritis, and vasculitis of the bowel manifesting as colicky pain or melena. It is more frequent in children, but can affect adults. HSP is associated with deposition of immunoglobulin A (IgA) in the glomeruli, cutaneous vasculature, and vasculature of the gastrointestinal tract. Even so, most classification systems for vasculitis do not use IgA deposition as a diagnostic marker for HSP, with the exception of the system developed by the European League Against Rheumatism (EULAR). HSP in children predicts renal dysfunction, hypertension, and preeclampsia in adulthood, but whether adults with HSP have altered progn…

Reviewing Author

Jeffrey P. Callen, MD

Disclosures

Consultant / Advisory board XOMA; Eli Lilly; Celgene

Equity Various trust accounts

Editorial boards JAMA Dermatology; UpToDate

Leadership positions in professional societies Association of Professors of Dermatology (President-Elect)

Jeffrey P. Callen, MD

Disclosures

Consultant / Advisory board XOMA; Eli Lilly; Celgene

Equity Various trust accounts

Editorial boards JAMA Dermatology; UpToDate

Leadership positions in professional societies Association of Professors of Dermatology (President-Elect)