Balding Chromosomes

Results of a genome-wide association study suggest HDAC9 as a new candidate gene for pattern baldness.

Male-pattern baldness (MPB) results from genetic predisposition and hormone dependency. Identical twins often have identical balding patterns and severity. The major genetic susceptibility loci on the X chromosome are the genes for the androgen hormone receptor and for the ectodysplasin A2 receptor. Another, less important susceptibility gene appears to be the paired box 1 (PAX1) locus on chromosome 20. Researchers in Germany performed another genome-wide association study to further probe genetic susceptibility to MPB.

The investigators compared gene polymorphism frequencies in two control groups (617 subjects) and a “severely affected” group (581 men from the most severely affected 10% of the population — aged <30 with Hamilton/Norwood gra…

Reviewing Author

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)

Mark V. Dahl, MD

Disclosures

Consultant / Advisory board Ulthera, Inc.; AuBio LifeSciences, LLC; Paris Therapeutics

Equity Elorac, Inc.; Makucell, Inc.; Paris Therapeutics

Editorial boards UpToDate

Leadership positions in professional societiesNational Rosacea Society (Chairman, Medical Board)