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Eccrine porocarcinoma (EPC), the most frequent variant of a heterogeneous group of adnexal tumors, originates from the acrosyringium. No consensus exists regarding the histologic criteria for classifying these tumors. To determine which characteristics of EPCs predict outcome, these authors reviewed clinical data from patient records and results of immunostaining for antiepidermal growth factor receptor (anti-EGFR) in 24 patients with EPCs (15 men; mean age, 72).
Histologic samples were classified as demonstrating one of three tumor subtypes: infiltrative, “pushing,” or pagetoid. Recurrences developed in eight patients (35%), five of whom had local, cutaneous recurrences and two of whom had regional recurrences in the lymph node. A statistic…