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Although most skin cancers are caused by excessive sun exposure, environmental chemicals have also been implicated in their development. Tobacco smoke contains such chemicals — polyaromatic hydrocarbons, which are known to cause cancer in the skin and other organs. Investigators performed a meta-analysis of published studies on the relationship between tobacco use and nonmelanoma skin cancer.
A search of four electronic databases identified 25 cohort and case-control studies published between 1950 and October 2010 on tobacco use and skin cancer that met the inclusion criteria. Tobacco exposure included cigarettes, cigars, and chewing tobacco. The data were insufficient to establish a clear association between tobacco use and nonmelanoma skin…