Fibroblastic Connective Tissue Nevus: A New Type of Dermal Fibroblastic/Myofibroblastic Lesion

Dermal fibroblastic/myofibroblastic proliferation characterizes a range of lesions with a common lineage but differing histology, clinical context, and behavior. Connective tissue nevus (CTN) is one such lesion; it can occur sporadically or associated with syndromes such as storiform collagenoma associated with Cowden syndrome. These authors analyzed the clinicopathologic presentation of a new CTN variant they call fibroblastic connective tissue nevus (FCTN).

In 25 cases (median age, 10 years; female:male ratio, 2:1)from a tertiary institution, the most frequent clinical presentation was of a single, slowly growing, painless plaque or nodule that had been present for a median of 1 year, with a mean size of 0.6 cm, and sited most frequently o…