Leukotriene B4: A Central Recruiter of Neutrophils in Allergic Dermatitis

LTB4-mediated attraction of neutrophils to skin subjected to tape stripping, a surrogate for scratching, is essential for development of allergic inflammation.

The itch–scratch cycle is a key component of exacerbations of atopic dermatitis (AD). Influx of T cells, particularly T helper 2 (Th2) cells, with eosinophils, has long been known to play a role in AD. Oyoshi and colleagues found a surprising new player.

They found that neutrophils are recruited to the superficial dermis of scratched skin in humans and tape-stripped skin in mice. Leukotriene B4 (LTB4), a known neutrophil chemoattractant, and its receptor BLT1 were elevated in such skin. LTB4 is generated from innate immune cells such as neutrophils, in response to a variety of stimuli.

Using a classic model of allergic dermatitis in mice, the investigators epicutaneously administered an ovalbumin challenge to sensitized mice. Ovalbumin-specif…

Reviewing Author

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

Leukotriene B4: A Central Recruiter of Neutrophils in Allergic Dermatitis

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Reviewing Author