Cutaneous T-Cell Lymphoma and Defective Apoptosis: Fas Pathway

Some CTCL phenotypes were associated with resistance to apoptosis.

Apoptosis maintains cellular homeostasis and eliminates unneeded T cells. Fas, a transmembrane death receptor, induces apoptosis by activation of caspases after binding to the Fas ligand (FasL). Functional studies in cell lines of cutaneous T-cell lymphomas (CTCLs) point to resistance to apoptosis caused by disruption to the Fas apoptotic pathway. Investigators retrospectively studied protein expression in the Fas pathway in patients with mycosis fungoides (MF) or CD30⁺ lymphoproliferative disorders (CD30⁺ ds).

They analyzed 36 MF samples and 36 CD30⁺ d samples (22 lymphomatoid papulosis [LYP], 10 anaplastic large cell lymphomas [ALCLs], and 4 borderline cases). Immunohistochemical studies showed that most MF cases were FasL-negative; 64% we…

Reviewing Author

Angelica Selim, MD

Disclosures

Grant / Research support NIH/NCI, The Plastic Surgery Foundation

Angelica Selim, MD

Disclosures

Grant / Research support NIH/NCI, The Plastic Surgery Foundation

Cutaneous T-Cell Lymphoma and Defective Apoptosis: Fas Pathway

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Reviewing Author