Newly Identified Psoriasis Susceptibility Loci

Disruptions of both innate and acquired immune regulation can influence the development of psoriasis.

Psoriasis is well known to have a critically important immune component. Many genome-wide association studies (GWAS) of psoriasis have identified genes involved in epidermal development and immune regulation. Tsoi and colleagues performed a meta-analysis of three GWAS and two independent data sets of genotyped individuals, with a focus on areas of the genome known to be important for immune function.

The researchers identified several new immune-related loci: Candidate genes STAT3, STAT5A, and STAT5B are transcription factors important for the differentiation of T_H17 cells; they regulate cytokines associated with psoriasis, such as interleukins IL-20, IL-22, and IL-23. RUNX3 is important for the formation of T_H1 CD4⁺ and CD8⁺ cells. The rese…

Reviewing Author

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology

Kenneth Y. Tsai, MD, PhD

Disclosures

Grant / Research support American Association for Cancer Research – Landon Foundation; National Institutes of Health/National Cancer Institute; Cancer Prevention Research Institute of Texas

Editorial BoardsJournal of the American Academy of Dermatology