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Angiocentric and angiodestruction are histologic findings frequently associated with aggressive lymphomas. Angiodestruction suggests a differential diagnosis of lymphoma with a T-cell or NK-cell origin and a rapidly fatal outcome. In this retrospective, clinicopathologic study, the authors characterized a subset of lymphomatoid papulosis (LyP) with an unusual angioinvasive or angiodestructive growth pattern that looks like aggressive T-cell lymphoma but has a benign outcome.
The authors examined 21 biopsy samples from 16 patients with LyP (M:F ratio, 3:1; median age, 61). The clinical presentation was of oligolesional papules and nodules that rapidly evolved to large, necrotic, ulcerated and eschar-like lesions, 1 to 4 cm in diameter. As in …