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Gastric cancer is a common cause of death worldwide, but with considerable geographic variation. Part of that variation might be due to differences in the prevalence of Helicobacter pylori infection, which is a major predisposing factor for both gastric lymphoma and adenocarcinoma of the stomach.
To further explore the association between H. pylori infection and gastric cancer, investigators in Taiwan conducted a prospective study among 1225 patients (mean age, 54; 66% men) with nonulcer dyspepsia, gastric ulcers, or duodenal ulcers. Half of the cohort was infected with H. pylori. All patients underwent upper endoscopy at baseline and at 1- to 3-year intervals thereafter.
During an average follow-up of 6.3 years, gastric cancer was diagnosed …