NSAID Therapy in Patients Taking Low-Dose Aspirin

At 12 weeks, the incidence of ulcers was similar among trial participants who took celecoxib alone and those who took naproxen with lansoprazole.

Many patients who require nonsteroidal anti-inflammatory drugs (NSAIDs) also require aspirin for cardiovascular prophylaxis; however, both these drugs are associated with gastroduodenal ulceration and gastrointestinal bleeding. What is the optimal approach to reducing the risk for GI complications in these patients: use of a cyclooxygenase-2–selective NSAID alone or use of a nonselective NSAID with a proton-pump inhibitor (PPI)?

To address this question, investigators at 81 study sites conducted a trial among 1045 osteoarthritic patients (all negative for Helicobacter pylori) who required both aspirin prophylaxis and NSAID therapy. Patients were randomized to receive either celecoxib alone (200 mg once daily) or naproxen (500 mg twice daily)…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose