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Observational studies and randomized controlled trials indicate that long-term aspirin use is associated with lower risk for colorectal cancer. Now, data from two additional studies support these results.
In the first study, 47,363 male health professionals were followed prospectively from 1986. During 18 years of follow-up (761,757 person-years), 975 cases of colorectal cancer developed. In multivariate analyses, aspirin use was associated with significantly lower colorectal cancer risk. This benefit required at least 6 to 10 years of regular use and disappeared within the first 4 years after aspirin use was discontinued. The effect was dose related and became significant at 2 to 5 standard aspirin tablets weekly (relative risk, 0.80); RRs …