H. pylori Eradication and Gastric Intestinal Metaplasia

Although histologic scores were not reduced with H. pylori eradication, the cellular phenotype of gastric intestinal metaplasia was changed in many patients.

Helicobacter pylori infection is associated with increased risk for gastric cancer. Whether H. pylori eradication affects this risk is unknown. To explore this issue, investigators in Japan evaluated changes in gastric intestinal metaplasia (GIM) and cellular markers of neoplasia after eradication.

Endoscopic biopsies were used to confirm H. pylori infection and to classify the 96 study participants into three groups:

Chronic gastritis (CG) group: 36 patients with CG but no GIM
Intestinal metaplasia (IM) group: 33 patients with CG and GIM
Dysplasia (DYS) group: 27 patients with GIM and DYS

All patients received proton-pump inhibitor–based triple therapy. Eradication of infection was confirmed by repeat endoscopy 2 to 3 months later and at yearly…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose