H. pylori’s Association with Adenocarcinoma, BE, and GERD

Helicobacter pylori seropositivity is associated with reduced risk for esophageal adenocarcinoma, Barrett esophagus, and gastroesophageal reflux disease.

Recent literature has suggested an inverse relation between Barrett esophagus and serologic evidence of Helicobacter pylori infection (Gut 2008; 57:727). Because BE is recognized as the primary risk factor for the development of esophageal adenocarcinoma (EAC), this inverse relation suggests that H. pylori infection might be protective against esophageal metaplasms and neoplasms.

To test this hypothesis, investigators in Ireland performed a case-control trial involving 227 patients with EAC, 224 patients with BE, 230 patients with gastroesophageal reflux disease, and 260 population-based controls. Of 905 patients with available samples, 455 were seropositive for H. pylori infection. Data on pepsinogen levels were available for 877 patients; …

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors