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Treatment of chronic liver disease is known to halt histologic damage. In addition, some evidence suggests that treatment of underlying hepatitis C virus (HCV) infection might lead to regression of fibrosis and cirrhosis. Now, investigators at a single tertiary care center in France have studied this possibility further.
The study cohort comprised 96 HCV-positive patients with biopsy-proven cirrhosis who received HCV treatment between 1988 and 2001 and were followed up every 6 months (median, 118 months). All patients were monoinfected, had Child-Pugh class A cirrhosis, and received conventional or pegylated interferon with or without ribavirin. Follow-up liver biopsies were performed a median of 17 months after the end of treatment. The mai…