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The investigators in this study previously used a probe-based, endoscopic, scattered-light fingerprinting technique to measure microvascular blood content in the colonic mucosa. They showed that, in animal models, normal mucosa near colon polyps and near cancer has an early increase in blood supply (EIBS). Now, the same investigators have measured the microvascular blood content in the cecum, mid-transverse colon, and rectum in 222 patients and have correlated these results with endoscopic findings to assess EIBS as a putative field effect marker for neoplasia risk.
The study cohort (40% women; mean age, 57) included 35 patients with nonadvanced adenomas and 12 with advanced adenomas. Demographic and risk factors were similar between patient…