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Specific blood-group antigens have been associated with peptic ulcers and gastric cancer, and might have a pathophysiologic role in Helicobacter pylori infection. However, we know little about the association between such antigens and nonvariceal upper gastrointestinal bleeding (UGIB).
To address the issue, researchers in Turkey prospectively studied 364 patients with UGIB from duodenal ulcers, gastric ulcers, or erosive gastritis at a single research hospital. Investigators compared the frequency of each of the blood-group antigens in the bleeding cohort with that in a control population of 734 blood donors from the same geographic area. The prevalence of H. pylori infection among the bleeding cohort was 50%.
More patients in the bleeding co…