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Interval colon cancers (diagnosed <5 years after negative colonoscopy) were shown to be more likely than noninterval cancers (diagnosed at first colonoscopy) to be located in the proximal colon and to demonstrate microsatellite instability (MSI; JW Gastroenterol Feb 2 2007). To investigate another molecular pathway implicated in the development of colon cancers, researchers examined CpG island methylator phenotype (CIMP) status in interval and noninterval colon cancers and explored a potential association between CIMP and MSI in interval cancers.
Using a Veterans Administration hospital registry of 1323 individuals who received diagnoses of colon cancer during a 17-year period, investigators identified 63 patients (98% male; 98% white) with …