A Genetic Basis of Nonalcoholic Fatty Liver Disease?

Two single nucleotide polymorphisms in the gene encoding apolipoprotein C3 were associated with NAFLD.

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with type 2 diabetes, hepatic insulin resistance, and hypertriglyceridemia. Recent studies suggest that two single nucleotide polymorphisms (SNPs; C-482T and T-455C) in the gene encoding apolipoprotein C3 (APOC3) are associated with hypertriglyceridemia. Are these SNPs also associated with NAFLD?

To find out, investigators evaluated the prevalence of C-482T and T-455C and the related effects these SNPs might have on lipid metabolism in a cohort of Asian Indian men, an ethnic group considered to be at high risk for NAFLD. The effect of weight loss on steatosis and insulin resistance was also studied. The findings were validated in a group of healthy non-Asian Indian men.

Among 95 …

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose