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Recent findings suggest that detection of advanced colorectal adenomas and colorectal cancers (CRCs) is uncommon when colonoscopy is repeated in asymptomatic individuals 5 years after an initial negative study (JW Gastroenterol Nov 7 2008).
To examine this issue further, investigators assessed 533 patients in a German national screening colonoscopy program who reported that they had undergone ≥1 negative colonoscopy ≥1 year earlier. Most of this cohort (75.4%) had undergone only one prior colonoscopy. Intervals since previous negative colonoscopies were 1 to 5 years in 21.5% of patients, 6 to 10 years in 31.1%, 11 to 15 years in 22%, and ≥16 years in 25.3%.
No CRCs were found during screening colonoscopy in patients who had received prior neg…