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Alarm symptoms in Western patients with dyspepsia have long been thought to increase the probability of upper gastrointestinal (GI) malignancy and, as such, to warrant endoscopic evaluation. Helicobacter pylori has been shown to be associated definitively with high risk for GI cancer, but whether alarm symptoms predict malignancy in populations with a high prevalence of H. pylori is unknown. To study this issue, investigators reviewed records of >100,000 consecutive patients in China with high background prevalence of H. pylori infection who underwent upper endoscopy for evaluation of dyspepsia during a 10-year period at a large tertiary medical center. The researchers evaluated data regarding patient age, alarm symptoms (bleeding, dysphagi…