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Hepatorenal syndrome is known to be associated with high morbidity and mortality in patients with cirrhosis, especially those with ascites. To characterize less well-understood forms of functional renal failure (FRF) in this clinical setting, investigators conducted a nested cohort study that was part of a long-term analysis of the natural history of ascites in patients with cirrhosis.
The researchers enrolled 263 patients (mean age, 61; 65% men) who experienced their first episodes of ascites-related decompensation during a 4-year period at two sites in Spain; all participants were followed for ≥6 months. Cirrhosis was related to hepatitis C virus infection in 52% of patients and to alcohol use in 48%. Renal failure was defined as a serum c…