A Statin and Antioxidants for Nonalcoholic Fatty Liver Disease?

Atorvastatin plus vitamins E and C reduced the odds of having NAFLD after about 4 years of therapy.

At present, we have no proven effective therapy for nonalcoholic fatty liver disease (NAFLD). Treatments including weight loss, insulin sensitization, and antioxidants such as vitamin E have been evaluated in many studies — most of them small and uncontrolled. In a prior randomized, controlled trial (JW Gastroenterol May 7 2010), vitamin E (800 IU/day) for 96 weeks was associated with improvement in nonalcoholic steatohepatitis (NASH), and both vitamin E and pioglitazone were associated with reductions in liver-enzyme levels and in hepatic steatosis. Now, researchers have evaluated the efficacy of a statin (atorvastatin) combined with two antioxidants (vitamins E and C) in individuals with NAFLD.

This investigation was part of the St. Franci…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose