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Aspirin in low doses (75–325 mg/day) is commonly used as secondary prophylaxis after cardiovascular thrombotic events. However, its value for primary prophylaxis is unclear because of evidence that it increases the risk for gastrointestinal bleeding.
To evaluate the risk for GI bleeding from low-dose aspirin alone or in combination with anticoagulants, clopidogrel, or proton-pump inhibitors (PPIs), investigators performed a meta-analysis of data from randomized controlled studies of any population taking low-dose aspirin on a daily basis. They identified 61 studies: 35 trials of aspirin alone, 18 with anticoagulants, 5 with clopidogrel, and 3 with PPIs.
The pooled analysis showed that low-dose aspirin alone slightly decreased all-cause mortal…