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Some studies suggest that patients with Barrett esophagus can reduce their risk for adenocarcinoma or high-grade dysplasia by taking nonsteroidal anti-inflammatory drugs (NSAIDs) or statins, but the evidence to date is limited. To further evaluate this possibility, investigators prospectively studied patients with Barrett esophagus at 15 hospitals in the Netherlands. Medication use was self-reported and validated using pharmacy records. Endoscopic surveillance was performed according to published guidelines.
During a median follow-up of 4.5 years, 38 of the 570 patients (7%) developed esophageal cancer or high-grade dysplasia. NSAID use and statin use were independently associated with a reduced risk for neoplastic progression (hazard ratio …