Elevated IgG4 in PSC Might Indicate More-Severe Disease

Serum immunoglobulin G4 levels >104 mg/dL were found in 22% of patients and were associated with higher Mayo risk scores.

Primary sclerosing cholangitis (PSC) is a cholestatic liver disease with a variable natural history; patients can have mild nonprogressive disease, associated bowel disease, severe progressive liver disease, or cholangiocarcinoma. Few factors have been identified to predict long-term outcome, and no specific therapy, including ursodeoxycholic acid, has been shown to improve survival.

Now, investigators in Canada have conducted a retrospective study to determine the clinical significance of immunoglobulin (Ig) G4 levels in 168 patients with documented PSC; of these, 55% had inflammatory bowel disease. The final study cohort comprised 101 patients with complete IgG4, clinical, radiographic, and laboratory data available.

IgG4 levels were elevat…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Elevated IgG4 in PSC Might Indicate More-Severe Disease

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Reviewing Author