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The first large randomized controlled trial of computed tomographic colonography (CTC) versus colonoscopy for colorectal cancer screening was recently conducted in the Netherlands (JW Gastroenterol Jan 6 2012). A higher rate of patients invited to undergo CTC versus colonoscopy actually underwent the test (34% vs. 22%). Detection of advanced neoplasia was higher with colonoscopy, but overall yield was equal after adjusting for higher adherence rates with CTC. Now, the same investigators report participants' expected and actual burdens of the two tests from preprocedure and postprocedure questionnaires.
The proposed preparation for CTC involved a noncathartic stool-labeling regimen, rather than purgation, as required for colonoscopy. The expe…