Treating Suspected EoE: Do Not Use pH Monitoring as a Guide

In a prospective study of patients with confirmed eosinophilic esophagitis, pH was a poor predictor of response to treatment.

Consensus guidelines for the diagnosis of eosinophilic esophagitis (EoE) require that gastroesophageal reflux disease (GERD) be excluded by a lack of clinical and histological response to acid suppression therapy or by negative results of pH monitoring. However, the overlap between these two diseases is increasingly recognized, making specific diagnosis and treatment a challenge. Now, investigators have evaluated the reliability of pH monitoring alone to guide treatment of patients with suspected EoE.

In a prospective study, industry-sponsored investigators enrolled 51 patients with a clinical diagnosis of EoE (defined as histological evidence of eosinophilic infiltration ≥15 eosinophils per high-power field and presence of dysphagia symptom…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors