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The prevalence of childhood asthma is increasing in developed countries. The reason for this effect is not clear, but prenatal exposure to a variety of environmental or medicinal agents has been speculated to play a role. A recent study suggested a potential association between asthma and prenatal exposure to acid-reducing drugs, including proton-pump inhibitors (PPIs).
To explore this possibility, researchers conducted a population-based cohort study, using data previously collected for all singleton births from 1996 through 2008 in northern Denmark. Maternal use of acid-reducing medications — PPIs or histamine-2 receptor antagonists (H2RAs) — was determined from the prescription database that tracks outpatient medication dispensation in th…